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最近の研究支援業績

  1. A rotating cerium anode X-ray system allows visualization of intramural coronary vessels after cardiac stem cell therapy for myocardial infarction. Tanaka C, Hosoda T, Ikeya Y, Shinozaki Y, Todoroki K, Shizuma T, Shiraishi T, Fukuyama N, Ueda T, Mori H. J Physiol Sci. 2018 Jul;68(4):345-353.
  2. Nectin-1 expression in cancer-associated fibroblasts is a predictor of poor prognosis for pancreatic ductal adenocarcinoma. Yamada M, Hirabayashi K, Kawanishi A, Hadano A, Takanashi Y, Izumi H, Kawaguchi Y, Mine T, Nakamura N, Nakagohri T. Surg Today. 2018 May;48(5):510-516.
  3. Autophagy?mediated adaptation of hepatocellular carcinoma cells to hypoxia? mimicking conditions constitutes an attractive therapeutic target. Owada S, Endo H, Shida Y, Okada C, Ito K, Nezu T, Tatemichi M. Oncol Rep. 2018 Apr;39(4):1805-1812.
  4. Amiloride Promotes Oligodendrocyte Survival and Remyelination after Spinal Cord Injury in Rats. Imai T, Katoh H, Suyama K, Kuroiwa M, Yanagisawa S, Watanabe M. J Clin Med. 2018 Mar 5;7(3). pii: E46.
  5. Cha-Koji, comprising green tea leaves fermented with Aspergillus luchuensis var kawachii kitahara, increases regulatory T cell production in mice and humans. Yamamoto B, Suzuki Y, Yonezu T, Mizushima N, Watanabe N, Sato T, Inoue S, Inokuchi S. Biosci Biotechnol Biochem. 2018 Mar 2:1-8.
  6. i-GONAD: a robust method for in situ germline genome engineering using CRISPR nucleases. Ohtsuka M, Sato M, Miura H, Takabayashi S, Matsuyama M, Koyano T, Arifin N, Nakamura S, Wada K, Gurumurthy CB. Genome Biol. 2018 Feb 26;19(1):25.
  7. Serum apolipoprotein E may be a novel biomarker of migraine. Yuasa N, Nagata E, Fujii N, Ito M, Tsukamoto H, Takizawa S. PLoS One. 2018 Jan 22;13(1):e0190620.
  8. Easi-CRISPR for creating knock-in and conditional knockout mouse models using long ssDNA donors. Miura H, Quadros RM, Gurumurthy CB, Ohtsuka M. Nat Protoc. 2018 Jan;13(1):195-215.
  9. Jagged1-induced Notch activation contributes to the acquisition of bortezomib resistance in myeloma cells. Muguruma Y, Yahata T, Warita T, Hozumi K, Nakamura Y, Suzuki R, Ito M, Ando K. Blood Cancer J. 2017 Dec 15;7(12):650.
  10. Imbalanced expression of polycistronic miRNA in acute myeloid leukemia. Kotaki R, Higuchi H, Ogiya D, Katahira Y, Kurosaki N, Yukihira N, Ogata J, Yamamoto H, Mohamad Alba S, Azhim A, Kitajima T, Inoue S, Morishita K, Ono K, Koyama-Nasu R, Kotani A. Int J Hematol. 2017 Dec;106(6):811-819.
  11. Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of neurexin in cerebellar cultures. Sato Y, Suzuki S, Iijima Y, Iijima T. Biochem Biophys Res Commun. 2017 Nov 18;493(2):1030-1036.
  12. Comparison of immune microenvironments between primary tumors and brain metastases in patients with breast cancer. Ogiya R, Niikura N, Kumaki N, Yasojima H, Iwasa T, Kanbayashi C, Oshitanai R, Tsuneizumi M, Watanabe KI, Matsui A, Fujisawa T, Saji S, Masuda N, Tokuda Y, Iwata H. Oncotarget. 2017 Oct 27;8(61):103671-103681.
  13. Hetero-oligomer of dynamin-related proteins participates in the fission of highly divergent mitochondria from Entamoeba histolytica. Makiuchi T, Santos HJ, Tachibana H, Nozaki T. Sci Rep. 2017 Oct 18;7(1):13439.
  14. Effect of end segment on physicochemical properties and platelet compatibility of poly(propylene glycol)-initiated poly(methyl methacrylate). Fukuda C, Yahata C, Kinoshita T, Watanabe T, Tsukamoto H, Mochizuki A. J Biomater Sci Polym Ed. 2017 Oct;28(14):1572-1587.
  15. A mutation in NOTCH1 ligand binding region detected in patients with oral squamous cell carcinoma reduces NOTCH1 oncogenic effect. Uchibori M, Aoyama KI, Ota Y, Kajiwara K, Tanaka M, Kimura M. Oncol Rep. 2017 Oct;38(4):2237-2242.
  16. Normal (123) I-MIBG uptake areas may be associated with hyperinnervation and arrhythmia risk in phenol model rabbit hearts. Amino M, Yoshioka K, Tanaka S, Kawabe N, Kurosawa H, Uchida K, Oshikiri S, Hashida T, Kanda S, Inokuchi S, Ikari Y. Pacing Clin Electrophysiol. 2017 Oct;40(10):1103-1112.
  17. AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway. Akatsuka H, Kuga S, Masuhara K, Davaadorj O, Okada C, Iida Y, Okada Y, Fukunishi N, Suzuki T, Hosomichi K, Ohtsuka M, Tanaka M, Inoue I, Kimura M, Sato T. Biochem Biophys Res Commun. 2017 Sep 30;491(4):1098-1104.
  18. Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons. Suzuki S, Ayukawa N, Okada C, Tanaka M, Takekoshi S, Iijima Y, Iijima T. Sci Rep. 2017 Sep 12;7(1):11405.
  19. An Adaptation System to Avoid Apoptosis via Autophagy Under Hypoxic Conditions in Pancreatic Cancer Cells. Owada S, Ito K, Endo H, Shida Y, Okada C, Nezu T, Tatemichi M. Anticancer Res. 2017 Sep;37(9):4927-4934.
  20. RXRB Is an MHC-Encoded Susceptibility Gene Associated with Anti-Topoisomerase I?Antibody-Positive Systemic Sclerosis. J Invest Dermatol. Oka A, Asano Y, Hasegawa M, Fujimoto M, Ishikawa O, Kuwana M, Kawaguchi Y, Yamamoto T, Takahashi H, Goto D, Endo H, Jinnin M, Mano S, Hosomichi K, Mabuchi T, Ueda MT, Nakagawa S, Beck S, Bahram S, Takehara K, Sato S, Ihn H. 2017 Sep;137(9):1878-1886.
  21. Platelet compatibility of magnesium alloys. Yahata C, Mochizuki A. Mater Sci Eng C Mater Biol Appl.
  22. A cell-based high-throughput screening assay system for inhibitor compounds of antigen presentation by HLA class II molecule. Watanabe N, Suzuki Y, Yonezu T, Nakagawa Y, Shiina T, Hirayama N, Inokuchi S, Inoue S. Sci Rep. 2017 Jul 28;7(1):6798.
  23. A portable system for rapid bacterial composition analysis using a nanopore-based sequencer and laptop computer. Mitsuhashi S, Kryukov K, Nakagawa S, Takeuchi JS, Shiraishi Y, Asano K, Imanishi T. Sci Rep. 2017 Jul 18;7(1):5657.
  24. Microneedle pH Sensor: Direct, Label-Free, Real-Time Detection of Cerebrospinal Fluid and Bladder pH. Mani GK, Miyakoda K, Saito A, Yasoda Y, Kajiwara K, Kimura M, Tsuchiya K. ACS Appl Mater Interfaces. 2017 Jul 5;9(26):21651-21659.
  25. Epidermoid cysts are a characteristic feature of intrapancreatic but not of extrapancreatic accessory spleens. Hirabayashi K, Yamada M, Kono H, Hadano A, Kawanishi A, Takanashi Y, Kawaguchi Y, Nakagohri T, Mine T, Nakamura N. Virchows Arch. 2017 Jul;471(1):91-98.
  26. Anti-Helicobacter pylori activity of non-living, heat-killed form of lactobacilli including Lactobacillus johnsonii No.1088. Aiba Y, Ishikawa H, Tokunaga M, Komatsu Y. FEMS Microbiol Lett. 2017 Jun 15;364(11).
  27. Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins. Quadros RM, Miura H, Harms DW, Akatsuka H, Sato T, Aida T, Redder R, Richardson GP, Inagaki Y, Sakai D, Buckley SM, Seshacharyulu P, Batra SK, Behlke MA, Zeiner SA, Jacobi AM, Izu Y, Thoreson WB, Urness LD, Mansour SL, Ohtsuka M, Gurumurthy CB. Genome Biol. 2017 May 17;18(1):92.
  28. 遺伝子を活用する能力を向上させるための高等学校「生物基礎」における遺伝子実験の試み. 井上 陽子, 谷口 泰史. 教育実践学論集. 2018 Mar 19:197-209.
  29. Impaired Autophagy in Retinal Pigment Epithelial Cells Induced from iPS Cells obtained from a Patient with Sialidosis. Davaadorj O, Akatsuka H, Yamaguchi Y, Okada C, Ito M, et al. Cell Dev Biol 2017 Sep 6(3):188.
  30. Inhibitory Effects of Valproic Acid in Oxaliplatin-Induced Neuropathy in Rat Model. Ren K, Yi K, Dai Y, Fujiwara M, Ohta T, Terayama H, Sakabe K, YiSQ. JJ Gastroenterol Hepatol Res. 2017 Dec 21;6(6):2461-2469.
  1. Identification of a novel alpha-fetoprotein-expressing cell population induced by the Jagged1/Notch2 signal in murine fibrotic liver. Nakano Y, Nakao S, Sumiyoshi H, Mikami K, Tanno Y, Sueoka M, Kasahara D, Kimura H, Moro T, Kamiya A, Hozumi K, Inagaki Y. Hepatol Commun. 2017 Mar 27;1(3):215-229.
  2. Adipocytes do not significantly contribute to plasma angiotensinogen. Koizumi M, Niimura F, Fukagawa M, Matsusaka T. J Renin Angiotensin Aldosterone Syst. 2016 Oct-Dec;17(4):1470320316672348.
  3. Immunohistochemical Ki67 after short-term hormone therapy identifies low-risk breast cancers as reliably as genomic markers. Iwamoto T, Katagiri T, Niikura N, Miyoshi Y, Kochi M, Nogami T, Shien T, Motoki T, Taira N, Omori M, Tokuda Y, Fujiwara T, Doihara H, Gyorffy B, Matsuoka J. Oncotarget. 2017 Apr 18;8(16):26122-26128.
  4. Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1. Sekihara K, Saitoh K, Han L, Ciurea S, Yamamoto S, Kikkawa M, Kazuno S, Taka H, Kaga N, Arai H, Miida T, Andreeff M, Konopleva M, Tabe Y. Oncotarget. 2017 May 23;8(21):34552-34564.
  5. Liposome-Encapsulated Hemoglobin Accelerates Skin Wound Healing in Diabetic dB/dB Mice. Fukui T, Kawaguchi AT, Takekoshi S, Miyasaka M, Sumiyoshi H, Tanaka R. Artif Organs. 2017 Apr;41(4):319-326.
  6. Behavior of DNA-lacking mitochondria in Entamoeba histolytica revealed by organelle transplant. Kazama M, Ogiwara S, Makiuchi T, Yoshida K, Nakada-Tsukui K, Nozaki T, Tachibana H. Sci Rep. 2017 Mar 13;7:44273.
  7. Foxc1 and Foxc2 are necessary to maintain glomerular podocytes. Motojima M, Kume T, Matsusaka T. Exp Cell Res. 2017 Mar 15;352(2):265-272.
  8. The effects of using vitrified chondrocyte sheets on pain alleviation and articular cartilage repair. Tani Y, Sato M, Maehara M, Nagashima H, Yokoyama M, Yokoyama M, Yamato M, Okano T, Mochida J. J Tissue Eng Regen Med. 2017 Dec;11(12):3437-3444.
  9. Platelet-activated serum might have a therapeutic effect on damaged articular cartilage. Yokoyama M, Sato M, Tani Y, Yokoyama M, Kokubo M, Yamato M, Okano T, Mochida J. J Tissue Eng Regen Med. 2017 Dec;11(12):3305-3312.
  10. Inducibility of Ventricular Arrhythmia 1 Year Following Treatment with Heavy Ion Irradiation in Dogs with Myocardial Infarction. Amino M, Yoshioka K, Furusawa Y, Tanaka S, Kawabe N, Hashida T, Tsukada T, Izumi M, Inokuchi S, Tanabe T, Ikari Y. Pacing Clin Electrophysiol. 2017 Apr;40(4):379-390.
  11. Monitoring Mitochondrial Complex-I Activity Using Novel PET Probe 18F-BCPP-EF Allows Early Detection of Radiotherapy Effect in Murine Squamous Cell Carcinoma. Murayama C, Kawaguchi AT, Kamijo A, Naito K, Kanazawa M, Tsukada H. PLoS One. 2017 Jan 26;12(1):e0170911.
  12. Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells. Tabe Y, Yamamoto S, Saitoh K, Sekihara K, Monma N, Ikeo K, Mogushi K, Shikami M, Ruvolo V, Ishizawa J, Hail N Jr, Kazuno S, Igarashi M, Matsushita H, Yamanaka Y, Arai H, Nagaoka I, Miida T, Hayashizaki Y, Konopleva M, Andreeff M. Cancer Res. 2017 Mar 15;77(6):1453-1464.
  13. Analysis to Estimate Genetic Variations in the Idarubicin-Resistant Derivative MOLT-3. Komiyama T, Ogura A, Hirokawa T, Zhijing M, Kamiguchi H, Asai S, Miyachi H, Kobayashi H. Int J Mol Sci. 2016 Dec 22;18(1). pii: E12.
  14. Losartan attenuates the coronary perivasculitis through its local and systemic anti-inflammatory properties in a murine model of Kawasaki disease. Suganuma E, Niimura F, Matsuda S, Ukawa T, Nakamura H, Sekine K, Kato M, Aiba Y, Koga Y, Hayashi K, Takahashi O, Mochizuki H. Pediatr Res. 2017 Apr;81(4):593-600.
  15. Serial Epithelial Lining Fluid Collection Using Bronchoscopic Microsampling in a Canine Lung Transplantation Model. Oiwa K, Kohno M, Hashimoto R, Nakagawa T, Masuda R, Nishiumi N, Kaga K, Iwazaki M. Tokai J Exp Clin Med. 2016 Dec 20;41(4):218-226.
  16. Mutations in the Mitochondrial ND1 Gene Are Associated with Postoperative Prognosis of Localized Renal Cell Carcinoma. Kim H, Komiyama T, Inomoto C, Kamiguchi H, Kajiwara H, Kobayashi H, Nakamura N, Terachi T. Int J Mol Sci. 2016 Dec 7;17(12). pii: E2049.
  17. Cytokine Elevation in Sudden Death With Respiratory Syncytial Virus: A Case Report of 2 Children. Kakimoto Y, Seto Y, Ochiai E, Satoh F, Osawa M. Pediatrics. 2016 Dec;138(6). pii: e20161293.
  18. Cilostazol protects against microvascular brain injury in a rat model of type 2 diabetes. Tsukamoto Y, Nagata E, Fukuyama N, Itoh Y, Yuzawa H, Kohara S, Shimizu M, Takahari Y, Takizawa S. Neurosci Res. 2017 Apr;117:48-53.
  19. Liposome-Encapsulated Hemoglobin Improves Tumor Oxygenation as Detected by Near-Infrared Spectroscopy in Colon Carcinoma in Mice. Kawaguchi F, Kawaguchi AT, Murayama C, Kamijo A, Haida M. Artif Organs. 2017 Apr;41(4):327-335.
  20. Loss of organic anion transporting polypeptide 1B3 function causes marked delay in indocyanine green clearance without any clinical symptoms. Kagawa T, Adachi Y, Hashimoto N, Mitsui H, Ohashi T, Yoneda M, Hasegawa I, Hirose S, Tsuruya K, Anzai K, Mine T. Hepatology. 2017 Mar;65(3):1065-1068.
  21. A Long-Gap Peripheral Nerve Injury Therapy Using Human Skeletal Muscle-Derived Stem Cells (Sk-SCs): An Achievement of Significant Morphological, Numerical and Functional Recovery. Tamaki T, Hirata M, Nakajima N, Saito K, Hashimoto H, Soeda S, Uchiyama Y, Watanabe M. PLoS One. 2016 Nov 15;11(11):e0166639.
  22. Comparison of the endothelial coverage in everolimus and zotarolimus-eluting stents in normal, atherosclerotic, and bifurcation rabbit iliac arteries. Torii S, Nakazawa G, Ijichi T, Yoshikawa A, Ohno Y, Ikari Y. Cardiovasc Interv Ther. 2018 Jan;33(1):55-61.
  23. Comparison of Vascular Responses Following New-Generation Biodegradable and Durable Polymer-Based Drug-Eluting Stent Implantation in an Atherosclerotic Rabbit Iliac Artery Model. Nakazawa G, Torii S, Ijichi T, Nagamatsu H, Ohno Y, Kurata F, Yoshikawa A, Nakano M, Shinozaki N, Yoshimachi F, Ikari Y. J Am Heart Assoc. 2016 Oct 19;5(10). pii: e003803.
  24. Carboxypeptidase E, Identified As a Direct Interactor of Growth Hormone, Is Important for Efficient Secretion of the Hormone. Mizutani A, Inoko H, Tanaka M. Mol Cells. 2016 Oct;39(10):756-761.
  25. The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype. Yabe M, Yabe H, Morimoto T, Fukumura A, Ohtsubo K, Koike T, Yoshida K, Ogawa S, Ito E, Okuno Y, Muramatsu H, Kojima S, Matsuo K, Hira A, Takata M. Br J Haematol. 2016 Nov;175(3):457-461.
  26. Production of a Locus- and Allele-Specific Monoclonal Antibody for the Characterization of SLA-1*0401 mRNA and Protein Expression Levels in MHC-Defined Microminipigs. Kametani Y, Ohshima S, Miyamoto A, Shigenari A, Takasu M, Imaeda N, Matsubara T, Tanaka M, Shiina T, Kamiguchi H, Suzuki R, Kitagawa H, Kulski JK, Hirayama N, Inoko H, Ando A. PLoS One. 2016 Oct 19;11(10):e0164995.
  27. Feasibility of photodynamic therapy for secondary hyperparathyroidism in chronic renal failure rats. Miyakogawa T, Kanai G, Tatsumi R, Takahashi H, Sawada K, Kakuta T, Fukagawa M. Clin Exp Nephrol. 2017 Aug;21(4):563-572.
  28. A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression. Kawaguchi M, Hara N, Bilim V, Koike H, Suzuki M, Kim TS, Gao N, Dong Y, Zhang S, Fujinawa Y, Yamamoto O, Ito H, Tomita Y, Naruse Y, Sakamaki A, Ishii Y, Tsuneyama K, Inoue M, Itoh J, Yasuda M, Sakata N, Jung CG, Kanazawa S, Akatsu H, Minato H, Nojima T, Asai K, Miura Y. BMC Cancer. 2016 Oct 18;16(1):805.
  29. Specific autoantigens identified by sera obtained from mice that are immunized with testicular germ cells alone. Terayama H, Hirai S, Naito M, Qu N, Katagiri C, Nagahori K, Hayashi S, Sasaki H, Moriya S, Hiramoto M, Miyazawa K, Hatayama N, Li ZL, Sakabe K, Matsushita M, Itoh M. Sci Rep. 2016 Oct 18;6:35599.
  30. Maintenance of Bone Homeostasis by DLL1-Mediated Notch Signaling. Muguruma Y, Hozumi K, Warita H, Yahata T, Uno T, Ito M, Ando K. J Cell Physiol. 2017 Sep;232(9):2569-2580.
  31. Effects of a cell-free method using collagen vitrigel incorporating TGF-ƒÀ1 on articular cartilage repair in a rabbit osteochondral defect model. Maruki H, Sato M, Takezawa T, Tani Y, Yokoyama M, Takahashi T, Toyoda E, Okada E, Aoki S, Mochida J, Kato Y. J Biomed Mater Res B Appl Biomater. 2017 Nov;105(8):2592-2602.
  32. Comparison of tumor-infiltrating lymphocytes between primary and metastatic tumors in breast cancer patients. Ogiya R, Niikura N, Kumaki N, Bianchini G, Kitano S, Iwamoto T, Hayashi N, Yokoyama K, Oshitanai R, Terao M, Morioka T, Tsuda B, Okamura T, Saito Y, Suzuki Y, Tokuda Y. Cancer Sci. 2016 Dec;107(12):1730-1735.
  33. Pronuclear Injection-Based Targeted Transgenesis. Schilit SL, Ohtsuka M, Quadros RM, Gurumurthy CB. Curr Protoc Hum Genet. 2016 Oct 11;91:15.10.1-15.10.28.
  34. Three-dimensional X-ray visualization of axonal tracts in mouse brain hemisphere. Mizutani R, Saiga R, Ohtsuka M, Miura H, Hoshino M, Takeuchi A, Uesugi K. Sci Rep. 2016 Oct 11;6:35061.
  35. Acetamiprid Accumulates in Different Amounts in Murine Brain Regions. Terayama H, Endo H, Tsukamoto H, Matsumoto K, Umezu M, Kanazawa T, Ito M, Sato T, Naito M, Kawakami S, Fujino Y, Tatemichi M, Sakabe K. Int J Environ Res Public Health. 2016 Sep 22;13(10). pii: E937.
  36. MicroRNA Stability in FFPE Tissue Samples: Dependence on GC Content. Kakimoto Y, Tanaka M, Kamiguchi H, Ochiai E, Osawa M. PLoS One. 2016 Sep 20;11(9):e0163125.
  37. Association of swine leukocyte antigen class II haplotypes and immune-related traits in a swine line selected for resistance to mycoplasmal pneumonia. Ando A, Shigenari A, Kojima-Shibata C, Nakajoh M, Suzuki K, Kitagawa H, Shiina T, Inoko H, Uenishi H. Comp Immunol Microbiol Infect Dis. 2016 Oct;48:33-40.
  38. Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice. Yanagawa T, Denda K, Inatani T, Fukushima T, Tanaka T, Kumaki N, Inagaki Y, Komada M. Am J Pathol. 2016 Oct;186(10):2751-60.
  39. Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain. Ishii T, Takanashi Y, Sugita K, Miyazawa M, Yanagihara R, Yasuda K, Onouchi H, Kawabe N, Nakata M, Yamamoto Y, Hartman PS, Ishii N. Aging Cell. 2017 Feb;16(1):39-51.
  40. Effect of Scavenging Circulating Reactive Carbonyls by Oral Pyridoxamine in Uremic Rats on Peritoneal Dialysis. Mori Y, Kakuta T, Miyakogawa T, Takekoshi S, Yuzawa H, Kobayashi H, Kawakami A, Miyata T, Fukagawa M. Ther Apher Dial. 2016 Dec;20(6):645-654.
  41. Cytocompatibility of magnesium and AZ31 alloy with three types of cell lines using a direct in vitro method. Mochizuki A, Yahata C, Takai H. J Mater Sci Mater Med. 2016 Sep;27(9):145.
  42. Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz MK, Sakai D, Masuda K, Ozaki T, Asahara H. Nat Commun. 2016 Aug 16;7:12503.
  43. Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice. Hadano S, Mitsui S, Pan L, Otomo A, Kubo M, Sato K, Ono S, Onodera W, Abe K, Chen X, Koike M, Uchiyama Y, Aoki M, Warabi E, Yamamoto M, Ishii T, Yanagawa T, Shang HF, Yoshii F. Hum Mol Genet. 2016 Aug 1;25(15):3321-3340.
  44. Identification of a virulence determinant that is conserved in the Jawetz and Heyl biotypes of [Pasteurella] pneumotropica. Sasaki H, Ishikawa H, Terayama H, Asano R, Kawamoto E, Ishibashi H, Boot R. Pathog Dis. 2016 Aug;74(6). pii: ftw066.
  45. Establishment of Nephrin Reporter Mice and Use for Chemical Screening. Tsuchida J, Matsusaka T, Ohtsuka M, Miura H, Okuno Y, Asanuma K, Nakagawa T, Yanagita M, Mori K. PLoS One. 2016 Jun 30;11(6):e0157497.
  46. Foetal hepatic progenitor cells assume a cholangiocytic cell phenotype during two-dimensional pre-culture. Anzai K, Chikada H, Tsuruya K, Ida K, Kagawa T, Inagaki Y, Mine T, Kamiya A. Sci Rep. 2016 Jun 23;6:28283.
  47. CD146 defines commitment of cultured annulus fibrosus cells to express a contractile phenotype. Nakai T, Sakai D, Nakamura Y, Nukaga T, Grad S, Li Z, Alini M, Chan D, Masuda K, Ando K, Mochida J, Watanabe M. J Orthop Res. 2016 Aug;34(8):1361-72.
  48. Relation between Carcinoembryonic Antigen Levels in Colon Cancer Tissue and Serum Carcinoembryonic Antigen Levels at Initial Surgery and Recurrence. Saito G, Sadahiro S, Okada K, Tanaka A, Suzuki T, Kamijo A. Oncology. 2016;91(2):85-9.
  49. Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2. Motojima M, Tanimoto S, Ohtsuka M, Matsusaka T, Kume T, Abe K. Cells Tissues Organs. 2016;201(5):380-9.
  50. Adhesive and robust multilayered poly(lactic acid) nanosheets for hemostatic dressing in liver injury model. Komachi T, Sumiyoshi H, Inagaki Y, Takeoka S, Nagase Y, Okamura Y. J Biomed Mater Res B Appl Biomater. 2017 Oct;105(7):1747-1757.
  51. Increase in Gene Expression of TYMP, DPYD and HIF1A Are Associated with Response to Preoperative Chemoradiotherapy Including S-1 or UFT for Rectal Cancer. Sadahiro S, Suzuki T, Tanaka A, Okada K, Saito G, Kamijo A, Nagase H. Anticancer Res. 2016 May;36(5):2433-40.
  52. Cartilage Oligomeric Matrix Protein Increases in Photodamaged Skin. Kobayashi M, Kawabata K, Kusaka-Kikushima A, Sugiyama Y, Mabuchi T, Takekoshi S, Miyasaka M, Ozawa A, Sakai S. J Invest Dermatol. 2016 Jun;136(6):1143-9.
  53. Molecular Characteristics of a Series of Clinical Isolates of Drug-Resistant Acinetobacter baumannii ST219 Strain: The Implications of a Sequence Analysis of the bla OXA-51-like. Umezawa K, Asai S, Iwashita H, Minakawa Y, Ohashi M, Ohshima T, Hayashi H, Matsui M, Inokuchi S, Miyachi H. J Emerg Med Trauma Surg Care 3: 017.
  54. 神経調節性失神におけるα2B-AR遺伝子多型 (Glu9/12ヘテロ型) とアデニル酸シクラーゼ活性量との関係. 小見山智義, 永田栄一郎, 神口浩, 橋田匡史, 坂間晋, 佐藤恭子, 佐倉宏, 吉岡公一郎, 小林広幸. 自律神経 54(1): 34-39.
  55. Characterization of layered chondrocyte sheets created in a co-culture system with synoviocytes in a hypoxic environment. Kokubo M, Sato M, Yamato M, Mitani G, Uchiyama Y, Mochida J, Okano T. J Tissue Eng Regen Med. 2017 Oct;11(10):2885-2894.
  1. MicroRNA deep sequencing reveals chamber-specific miR-208 family expression patterns in the human heart. Kakimoto Y, Tanaka M, Kamiguchi H, Hayashi H, Ochiai E, Osawa M. Int J Cardiol. 2016 May 15;211:43-8.
  2. Infertility and recurrent miscarriage with complex II deficiency-dependent mitochondrial oxidative stress in animal models. Ishii T, Yasuda K, Miyazawa M, Mitsushita J, Johnson TE, Hartman PS, Ishii N. Mech Ageing Dev. 2016 Apr;155:22-35.
  3. Molecular alterations in sporadic pancreatic neuroendocrine microadenomas. Hadano A, Hirabayashi K, Yamada M, Kawanishi A, Takanashi Y, Kawaguchi Y, Nakagohri T, Nakamura N, Mine T. Pancreatology. 2016 May-Jun;16(3):411-5.
  4. Transplantation of activated nucleus pulposus cells after cryopreservation: efficacy study in a canine disc degeneration model. Nukaga T, Sakai D, Tanaka M, Hiyama A, Nakai T, Mochida J. Eur Cell Mater. 2016 Jan 27;31:95-106.
  5. Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells. Tabe Y, Hatanaka Y, Nakashiro M, Sekihara K, Yamamoto S, Matsushita H, Kazuno S, Fujimura T, Ikegami T, Nakanaga K, Matsumoto H, Ueno T, Aoki J, Yokomizo T, Konopleva M, Andreeff M, Miida T, Iwabuchi K, Sasai K. Int J Radiat Biol. 2016;92(1):24-34.
  6. miR-133 regulates Evi1 expression in AML cells as a potential therapeutic target. Yamamoto H, Lu J, Oba S, Kawamata T, Yoshimi A, Kurosaki N, Yokoyama K, Matsushita H, Kurokawa M, Tojo A, Ando K, Morishita K, Katagiri K, Kotani A. Sci Rep. 2016 Jan 12;6:19204.
  7. A Combination of Mitochondrial Oxidative Stress and Excess Fat/Calorie Intake Accelerates Steatohepatitis by Enhancing Hepatic CC Chemokine Production in Mice. Moro T, Nakao S, Sumiyoshi H, Ishii T, Miyazawa M, Ishii N, Sato T, Iida Y, Okada Y, Tanaka M, Hayashi H, Ueha S, Matsushima K, Inagaki Y. PLoS One. 2016 Jan 8;11(1):e0146592.
  8. Altered blood flow in cerebral perforating arteries of rat models of diabetes: A synchrotron radiation microangiographic study toward clinical evaluation of white matter hyperintensities. Fukuyama N, Tsukamoto Y, Takizawa S, Ikeya Y, Fujii T, Shinozaki Y, Takahari Y, Kawabe N, Wakana N, Umetani K, Todoroki K, Fukui S, Tanaka C, Tanaka E, Mori H. Geriatr Gerontol Int. 2015 Dec;15 Suppl 1:74-80.
  9. Treatment with Anti-Fc??RI?? (MAR-1) Antibody Prevents Acute Islet Allograft Rejection in a Murine Model. Yazawa N, Imaizumi T, Makuuchi H, Tsuchiya I, Tanaka M, Inokuchi S, Habu S, Nakagohri T. Tokai J Exp Clin Med. 2015 Dec 20;40(4):141-8.
  10. Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis. Imai J, Hozumi K, Sumiyoshi H, Yazawa M, Hirano K, Abe J, Higashi K, Inagaki Y, Mine T. Biochem Biophys Res Commun. 2015 Dec 25;468(4):554-60.
  11. Investigation of bipotent differentiation of hepatoblasts using inducible diphtheria toxin receptor-transgenic mice. Yanagida A, Mizuno N, Yamazaki Y, Kato-Itoh M, Umino A, Sato H, Ito K, Yamaguchi T, Nakauchi H, Kamiya A. Hepatol Res. 2016 Jul;46(8):816-28.
  12. Abnormal gait, reduced locomotor activity and impaired motor coordination in Dgcr2-deficient mice. Mugikura SI, Katoh A, Watanabe S, Kimura M, Kajiwara K. Biochem Biophys Rep. 2015 Nov 18;5:120-126.
  13. Assessment of the Safety of Chondrocyte Sheet Implantation for Cartilage Regeneration. Yokoyama M, Sato M, Umezawa A, Mitani G, Takagaki T, Yokoyama M, Kawake T, Okada E, Kokubo M, Ito N, Takaku Y, Murai K, Matoba R, Akutsu H, Yamato M, Okano T, Mochida J. Tissue Eng Part C Methods. 2016 Jan;22(1):59-68.
  14. Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system. Motojima M, Ogiwara S, Matsusaka T, Kim SY, Sagawa N, Abe K, Ohtsuka M. Mamm Genome. 2016 Feb;27(1-2):62-9.
  15. Simultaneous Intravascular Ultrasound Usage Overcomes Misinterpretation When Evaluating Lipid-Rich Plaques With Optical Frequency Domain Imaging--Ex Vivo Study. Torii S, Nakazawa G, Ijichi T, Yoshikawa A, Murakami T, Natsumeda M, Fujii T, Shinozaki N, Yoshimachi F, Morino Y, Ikari Y. Circ J. 2015;79(12):2641-7.
  16. FLT3-ITD drives Ara-C resistance in leukemic cells via the induction of RUNX3. Damdinsuren A, Matsushita H, Ito M, Tanaka M, Jin G, Tsukamoto H, Asai S, Ando K, Miyachi H. Leuk Res. 2015 Dec;39(12):1405-13.
  17. The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. Harada M, Benito J, Yamamoto S, Kaur S, Arslan D, Ramirez S, Jacamo R, Platanias L, Matsushita H, Fujimura T, Kazuno S, Kojima K, Tabe Y, Konopleva M. Oncotarget. 2015 Nov 10;6(35):37930-47.
  18. The basic helix-loop-helix transcription factor, Mist1, induces maturation of mouse fetal hepatoblasts. Chikada H, Ito K, Yanagida A, Nakauchi H, Kamiya A. Sci Rep. 2015 Oct 12;5:14989.
  19. A method for estimating spatial resolution of real image in the Fourier domain. Mizutani R, Saiga R, Takekoshi S, Inomoto C, Nakamura N, Itokawa M, Arai M, Oshima K, Takeuchi A, Uesugi K, Terada Y, Suzuki Y. J Microsc. 2015 Jan;261(1):57-66.
  20. Inositol Hexakisphosphate Kinase 2 Promotes Cell Death in Cells with Cytoplasmic TDP-43 Aggregation. Nagata E, Nonaka T, Moriya Y, Fujii N, Okada Y, Tsukamoto H, Itoh J, Okada C, Satoh T, Arai T, Hasegawa M, Takizawa S. Mol Neurobiol. 2016 Oct;53(8):5377-83.
  21. Cognitive Function Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in Eutherians. Irie M, Yoshikawa M, Ono R, Iwafune H, Furuse T, Yamada I, Wakana S, Yamashita Y, Abe T, Ishino F, Kaneko-Ishino T. PLoS Genet. 2015 Sep 24;11(9):e1005521.
  22. Outbreak of drug-resistant Acinetobacter baumannii ST219 caused by oral care using tap water from contaminated hand hygiene sinks as a reservoir. Umezawa K, Asai S, Ohshima T, Iwashita H, Ohashi M, Sasaki M, Kaneko A, Inokuchi S, Miyachi H. Am J Infect Control. 2015 Nov;43(11):1249-51.
  23. Reduction in amino-acid-induced anti-hypothermic effects during general anesthesia in ovariectomized rats with progesterone replacement. Kanazawa M, Watanabe M, Suzuki T. J Anesth. 2016 Feb;30(1):123-31.
  24. Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing: Mafa-class I polymorphism. Shiina T, Yamada Y, Aarnink A, Suzuki S, Masuya A, Ito S, Ido D, Yamanaka H, Iwatani C, Tsuchiya H, Ishigaki H, Itoh Y, Ogasawara K, Kulski JK, Blancher A. Immunogenetics. 2015 Oct;67(10):563-78.
  25. Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185. Tabe Y, Kojima K, Yamamoto S, Sekihara K, Matsushita H, Davis RE, Wang Z, Ma W, Ishizawa J, Kazuno S, Kauffman M, Shacham S, Fujimura T, Ueno T, Miida T, Andreeff M. PLoS One. 2015 Sep 4;10(9):e0137210.
  26. Assessment of Artificial MiRNA Architectures for Higher Knockdown Efficiencies without the Undesired Effects in Mice. Miura H, Inoko H, Tanaka M, Nakaoka H, Kimura M, Gurumurthy CB, Sato M, Ohtsuka M. PLoS One. 2015 Aug 18;10(8):e0135919.
  27. CRISPR/Cas9-based generation of knockdown mice by intronic insertion of artificial microRNA using longer single-stranded DNA. Miura H, Gurumurthy CB, Sato T, Sato M, Ohtsuka M. Sci Rep. 2015 Aug 5;5:12799.
  28. Activity-Dependent Bidirectional Regulation of GAD Expression in a Homeostatic Fashion Is Mediated by BDNF-Dependent and Independent Pathways. Hanno-Iijima Y, Tanaka M, Iijima T. PLoS One. 2015 Aug 4;10(8):e0134296.
  29. MEK-ERK Activity Regulates the Proliferative Activity of Fetal Hepatoblasts Through Accumulation of p16/19(cdkn2a). Kamiya A, Ito K, Yanagida A, Chikada H, Iwama A, Nakauchi H. Stem Cells Dev. 2015 Nov 1;24(21):2525-35.
  30. Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner. Yanagida A, Chikada H, Ito K, Umino A, Kato-Itoh M, Yamazaki Y, Sato H, Kobayashi T, Yamaguchi T, Nakayama KI, Nakauchi H, Kamiya A. Dev Biol. 2015 Nov 15;407(2):331-43.
  31. GONAD: Genome-editing via Oviductal Nucleic Acids Delivery system: a novel microinjection independent genome engineering method in mice. Takahashi G, Gurumurthy CB, Wada K, Miura H, Sato M, Ohtsuka M. Sci Rep. 2015 Jun 22;5:11406.
  32. Multi-Acupuncture Point Injections and Their Anatomical Study in Relation to Neck and Shoulder Pain Syndrome (So-Called Katakori) in Japan. Terayama H, Yamazaki H, Kanazawa T, Suyama K, Tanaka O, Sawada M, Ito M, Ito K, Akamatsu T, Masuda R, Suzuki T, Sakabe K. PLoS One. 2015 Jun 5;10(6):e0129006.
  33. MicroRNA Stability in Postmortem FFPE Tissues: Quantitative Analysis Using Autoptic Samples from Acute Myocardial Infarction Patients. Kakimoto Y, Kamiguchi H, Ochiai E, Satoh F, Osawa M. PLoS One. 2015 Jun 5;10(6):e0129338.
  34. Study of the water structure in poly(methyl methacrylate-block-2-hydroxyethyl methacrylate) and its relationship to platelet adhesion on the copolymer surface. Mochizuki A, Namiki T, Nishimori Y, Ogawa H. J Biomater Sci Polym Ed. 2015;26(12):750-65.
  35. Aggregation of rare/low-frequency variants of the mitochondria respiratory chain-related proteins in rheumatoid arthritis patients. Mitsunaga S, Hosomichi K, Okudaira Y, Nakaoka H, Suzuki Y, Kuwana M, Sato S, Kaneko Y, Homma Y, Oka A, Shiina T, Inoko H, Inoue I. J Hum Genet. 2015 Aug;60(8):449-54.
  36. Delta-like 4-mediated Notch signaling is required for early T-cell development in a three-dimensional thymic structure. Hirano K, Negishi N, Yazawa M, Yagita H, Habu S, Hozumi K. Eur J Immunol. 2015 Aug;45(8):2252-62.
  37. Disappearance of centroacinar cells in the Notch ligand-deficient pancreas. Nakano Y, Negishi N, Gocho S, Mine T, Sakurai Y, Yazawa M, Abe K, Yagita H, Habu S, Kageyama R, Kawaguchi Y, Hozumi K. Genes Cells. 2015 Jun;20(6):500-11.
  38. One-step generation of multiple transgenic mouse lines using an improved Pronuclear Injection-based Targeted Transgenesis (i-PITT). Ohtsuka M, Miura H, Mochida K, Hirose M, Hasegawa A, Ogura A, Mizutani R, Kimura M, Isotani A, Ikawa M, Sato M, Gurumurthy CB. BMC Genomics. 2015 Apr 9;16:274.
  39. Relationship between human evolution and neurally mediated syncope disclosed by the polymorphic sites of the adrenergic receptor gene ??2B-AR. Komiyama T, Hirokawa T, Sato K, Oka A, Kamiguchi H, Nagata E, Sakura H, Otsuka K, Kobayashi H. PLoS One. 2015 Apr 10;10(4):e0120788.
  40. Human pluripotent stem cell-derived cholangiocytes: current status and future applications. Kamiya A, Chikada H. Curr Opin Gastroenterol. 2015 May;31(3):233-8.
  41. Unilateral ureteral obstruction attenuates intrarenal angiotensin II generation induced by podocyte injury. Okabe M, Miyazaki Y, Niimura F, Pastan I, Nishiyama A, Yokoo T, Ichikawa I, Matsusaka T. Am J Physiol Renal Physiol. 2015 Apr 15;308(8):F932-7.

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